生物学杂志
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摘要： CD4+辅助性 T细胞（Th细胞）在抗原刺激与机体微环境调控下分化发育为不同的细胞亚群以对抗或适应外界环境改变，而分化过程受控于由细胞因子和转录因子所组成的复杂调控网络。表观遗传学是研究不涉及DNA序列变化的DNA甲基化谱、染色质结构状态等对基因表达的改变，并在亲代与子代之间传递的一门科学。表观遗传对免疫细胞的分化调控和Th细胞亚群可遗传性等方面具有重要影响。
关键词: 表观遗传学, Th细胞, 分化
Abstract: CD4+ helper T cells (Th cells) differentiate into different cell subsets in order to resist or adapt to the environment changes under the condition of antigen stimulation and body micro-environment, and the process of cells differentiation is controlled by the complex regulatory network of cytokines and transcription factors.Epigenetics is a science that does not involve the change of DNA sequences and changes gene expression such as DNA methylation and chromatin structure, and passes between the parental and filial generation.Epigenetics have an important influence on the differentiation regulation of immune cells and the heritability of T helper cell lineage.
Key words: epigenetics, T helper cells, differentiation
淮文英， 杨福权， 唐玉琴， 张天娥， 刘伟伟. 表观遗传学调控Th细胞分化发育的研究进展[J]. 生物学杂志.
HUAI Wen-ying, YANG Fu-quan, TANG Yu-qin, ZHANG Tian-e, LIU Wei-wei. The research progress of epigenetic regulation of T helper cell differentiation[J]. .
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