生物学杂志

生物学杂志 ›› 2022, Vol. 39 ›› Issue (4): 104-.doi: 10.3969/j.issn.2095-1736.2022.04.104

• 综述与专论 • 上一篇    下一篇

DNA感受器在鱼类先天免疫中的功能

  

  1. 1. 豫章师范学院 小学教育学院， 南昌 330103； 2. 南昌大学 生命科学学院， 南昌 330031
  • 出版日期:2022-08-18 发布日期:2022-08-15
  • 作者简介:吴初新，博士，教授，主要从事鱼类先天免疫的研究，E-mail: chuxin7072@163.com
  • 基金资助:
    江西省自然科学基金项目(20202BABL205009)； 江西省教育厅科学技术研究项目(GJJ191210)

Functions of DNA sensors in innate immunity of fish

  1. 1. School of Primary School Education, Yuzhang Normal University, Nanchang 330103, China;
    2. College of Life Sciences, Nanchang University, Nanchang 330031, China
  • Online:2022-08-18 Published:2022-08-15

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摘要： 综述鱼类胞内主要的DNA感受器，包括TLR9/TLR21、STING、cGAS、DDX41和PKZ等的结构、DNA识别机制，分析这些DNA感受器在感知病原微生物所释放的DNA后激活的信号通路、诱导产生I型IFN或炎症因子的分子机制。同时，分析鱼类与哺乳类的DNA感受器的不同之处，提出当前鱼类DNA感受器研究中的不足，为后续深入研究提供参考。

关键词: 鱼类, DNA感受器, 信号通路, 先天免疫

Abstract: This paper reviewed the structures and DNA recognition mechanisms of the main DNA sensors in fish, including TLR9/TLR21, STING, cGAS, DDX41 and PKZ. These DNA sensors could detect the DNA of pathogenic microorganisms, and finally induced the expression of type I IFN and inflammatory factors through a series of signal transduction. In addition, this review analyzed the differences of DNA sensors between fish and mammals, and discussed the deficiencies in the current research of fish DNA sensors. It provided theoretical guidance for further study of fish DNA sensors.

Key words: fish, DNA sensors, signal pathway, innate immune

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