生物学杂志

生物学杂志

• 综述与专论 • 上一篇    下一篇

Pyk2参与细胞信号转导通路的研究进展

  

  1. 1. 中国医科大学 附属口腔医院口腔生物学教研室； 2. 中国医科大学 附属口腔医院牙周科， 沈阳 110002
  • 出版日期:2018-04-18 发布日期:2018-04-18
  • 通讯作者: 寇育荣，副教授，博士，研究方向为牙周微生物学，E-mail：kouyurong2005@aliyun.com
  • 作者简介:武茜茗，硕士研究生，研究方向为牙周微生物学，E-mail：lolo140203@sina.com
  • 基金资助:
    国家自然科学基金资助项目(编号:81300886)

The research advance of Pyk2 involved in signal transduction pathways

  1. 1. Department of Oral Biology, School of Stomatology; 2. Department of Periodontics, School of Stomatology,China Medical University, Shenyang 110002, China
  • Online:2018-04-18 Published:2018-04-18

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摘要： 富含脯氨酸的酪氨酸激酶2（proline-rich tyrosine kinase 2，Pyk2）广泛存在于细胞和组织中，参与多种生理及病理过程，发挥其生物学效应。Pyk2依赖N-末端、C-末端和中心激酶结构3个部分实现其对细胞外信号的迅速反应，通过膜联受体活化及自磷酸化等机制实现其自身的活化，激活下游信号分子，进而启动细胞信号转导通路，最终发生一系列细胞形态及功能变化。就目前对Pyk2参与细胞信号转导通路的研究进行综述，以期深入而全面地了解Pyk2的作用，为相关疾病的诊疗提供新的思路。

关键词: Pyk2, 分子结构, 信号通路, 作用机制

Abstract: Proline-rich tyrosine kinase 2 (Pyk2) widely exists in cells and tissues, involved in multiple physiological and pathological processes and exerts biological influence. Pyk2 can rapidly response to the extracellular signals depending on the structures of a central kinase domain and its flanked N-and C-terminal domains. It excites the downstream signaling molecules through activation of coupling receptors and autophosphorylation, initiates corresponding cell signal transduction pathways, and ultimately results in a series of cellular morphological and functional changes. In this review, we reviewed the research of Pyk2 involving in cell signal transduction pathways so far in order to comprehensively understand the role of Pyk2 and provide new perspectives for diagnosis and treatment of related diseases.

Key words: Pyk2, molecular structure, signal pathway, mechanism