生物学杂志

生物学杂志 ›› 2022, Vol. 39 ›› Issue (1): 89-.doi: 10. 3969/ j. issn. 2095-1736. 2022. 05. 01. 089

• 综述与专论 • 上一篇    下一篇

稳态磁场与药物联用对肿瘤细胞的生物学效应研究进展

  

  1. 1. 中国科学院合肥物质科学研究院强磁场科学中心, 合肥230031;2. 中国科学技术大学科学岛分院, 合肥230036
  • 出版日期:2022-02-18 发布日期:2022-02-15
  • 通讯作者: 李志元,博士,副研究员,研究方向为稳态磁场对自噬的调控,E-mail:lizhiyuan@hmfl.ac.cn
  • 作者简介:张宁,硕士研究生,研究方向为稳态磁场与药物联用,E-mail: zhangnin@mail.ustc.edu.cn
  • 基金资助:
    国家自然科学基金资助项目(31900508); 中国科学院合肥物质科学研究院院长基金资助项目(YZJJ2019QN17); 安徽省自然科学基金资助项目(1908085MC88)

Research advances in biological effects of static magnetic field combined with drugs on tumor cells

  1. 1. High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences,Hefei 230031, China; 2. Science Island Branch of Graduate School, University of Science and Technology of China,Hefei 230036, China
  • Online:2022-02-18 Published:2022-02-15

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摘要：

稳态磁场对肿瘤具有抑制效应,与药物联用以提高药效的研究取得多项进展。系统分析稳态磁场联合常用药物如平阳霉素、顺铂、阿霉素、5-氟尿嘧啶、紫杉醇、维生素D、辣椒素等对肿瘤细胞的生物学效应,发现特定强度的稳态磁场联合特定药物,可以显著降低药物的使用浓度和毒副作用,但对部分肿瘤具有拮抗作用或无明显影响。因此,稳态磁场与药物联用的生物学效应依赖于药物种类、磁场强度和细胞类型等。综述磁场与不同药物联用效应的研究进展,为临床上稳态磁场和药物联用提供参考。


关键词: 稳态磁场, 肿瘤细胞, 药物联用

Abstract: Static magnetic fields (SMFs) have an inhibitory effect on tumors, and many advances have been made in combination with drugs to improve the efficacy of tumors. Herein after a detailed review of the effects of static magnetic fields combined with commonly used drugs such as pingyangmycin, cisplatin, doxorubicin, 5-fluorouracil, paclitaxel, vitamin D, capsaicin, etc on tumor cells, it was found that static magnetic fields of specific intensity combined with specific drugs could significantly reduce the concentration and side effects of the drug, but it had an antagonistic effect or no obvious effect on some tumors. Therefore, the biological effects of SMF-drug combination depend on drug type, magnetic field intensity, and cell type. The research advances were reviewed on effects of magnetic field combined with different drugs, in order to provide a reference for clinically static magnetic field and drug combination.

Key words: static magnetic field, tumor cell, drug combination

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