Abstract: The construction of course knowledge system is always the fundamental of course construction and teaching reform. The knowledge system of cell biology course was deconstructed by using PBL model in order to straighten out the relationship among cytology, cell biology and molecular cell biology, to emphasis on its key points, to resolve its difficulty points and to take into account its hot points. It is helpful for teachers and students to better grasp the main goals and tasks of cell biology course, and to improve the level of teaching and learning. At the same time, the author puts forward the experience of teaching under the knowledge system of the course for many years, which can be used for reference.

Key words: cell biology, course, knowledge system, deconstruction, teaching experience