Abstract: Antibiotics play important roles in the treatment of malaria, tuberculosis and other infectious diseases. However, the abuse of antibiotics causes more drug-resistant beacteria, which leads to the exhausting of effective antibiotics resources. Therefore, it is urgent to seek out new antimicrobial agents or enhancers of the efficacy of antibiotics. The mechanosensitive channel of large conductance (MscL) is a kind of channel proteins located in the plasma membrane of bacteria, which directly senses the change of membrane tension to open up, and a wide range of molecules can go through. MscL is widely spreaded in the whole bacterial kingdom, and the amino acid sequence of MscLs are highly conserved in bacterial species. However, there is no MscL homologue in humans and mammals. Recently, MscL is an attractive target in the research and development of new drug. So, this review focused on the interaction between MscL and antibiotics and its potential use.

Key words: antibiotic-resistant, MscL, channel protein, antibiotic, bacteria