In the present study, seasonal changes of thermomoneutral zone (TNZ) and evaporative water loss (EWL) were measured in Apodemus chevrieri. The results showed that TNZ was 20～27.5℃ in winter, 22.5～27.5℃ in summer, respectively. Body mass, body temperature (Tb), EWL, evaporative water loss/metabolic rate (EWL/RMR) and evaporative heat loss/total heat production (EHL/HP) were significant higher in summer than that in winter, but basic metabolic rate and metabolic water production/evaporative water loss （MWP/EWL）were lower in summer than that in winter. All of the results suggested that the shift of the lower critical temperature of TNZ is possibly associated with the rate of metabolism and ambient temperature (T_a). The upper critical temperature of TNZ may be independent of the changes in T_a. The changes of lower critical temperature of TNZ are an important strategy in adaptation to variations of T_a in A. chevrieri. Moreover, it decreased EWL and EHL/HP to cope with the cold and dry environments in winter.