Abstract: This work focused on histological study on adipose tissue in Tupaia belangeri by paraffin section, HE staining, immunohistochemistry and immunofluorescence staining. The results showed that the morphological changes of adipocytes in the Tupaia belangeri were observed under the action of high-glucose-fat-diet, and the large number of adipocytes of small fat droplets appeared, and the diameter of fat droplets became larger. The expression of UCP1 was increased at 28 d, and decreased at 49 d after exposure to white adipose tissue and brown adipose tissue. This study showed that there was beige in white adipose tissue, high-glucose-fat-diet had an induction of heat production, too obese, and the animal′s heat will be reduced.

Key words: Tupaia belangeri, high-glucose-fat-diet, adipose tissue, beige