Abstract: AMP-activated protein kinase (AMPK) is widely existed in eukaryotes and has vital function in energy metabolism. AMPK could be activated by Liver kinase B1 (LKB1) and calmodulin-dependent protein kinases β (CaMKKβ)， and it regulates the metabolism of fat, protein and glucose to balance the energy metabolism. Moreover, activator, inhibitor and cytokines regulate energy metabolism through up-regulation or down-regulation of AMPK expression.

Key words: AMPK； energy metabolism, activator and inhibitor, cytokines