To determine and compare the parameters of blood, heart rate, carotid artery pressure, ventricular pressure and organ indexes between conventional and specific pathogen free (SPF) FMMU albino guinea-pig, a total of 30 conventional guinea-pig and 30 SPF guinea-pig about 250-350 g weight were fed for a week, then blood physiological and biochemical indexes; blood gas and carotid artery pressure were determined; the ventricular pressure was measured by arterial catheterization, and heart rate was measured on the respiratory support condition. Finally, weight of guinea-pig body and main organ was weighed. Comparison of SPF and conventional FMMU albimo guinea-pig showed that the difference of 10 blood physiological indexes, 14 blood biochemical indexes and 15 blood gas indexes were totally significant

FMMU albino guinea-pig, blood parameter, carotid artery pressure, ventricular pressure, organ