生物学杂志

生物学杂志 ›› 2019, Vol. 36 ›› Issue (5): 31-.doi: 10.3969/j.issn.2095-1736.2019.05.031

• 研究报告 • 上一篇    下一篇

真核微藻糖转运蛋白基因的比较基因组学分析

  

  1. 1. 中国科学院 烟台海岸带研究所 海岸带生物学与生物资源利用重点实验室, 烟台 264003;
    2. 中国科学院大学, 北京 101418; 3. 山东省农业科学院 生物技术研究中心， 济南 250100;
    4. 山东省作物遗传改良与生态生理重点实验室， 济南 250100;5. 山西农业大学 分子农业与生物能源研究所, 太谷 030801
  • 出版日期:2019-10-18 发布日期:2019-10-11
  • 通讯作者: 崔红利， 博士， 副教授，研究方向为藻类生物技术， E-mail: cuihongli@sxau.edu.cn
  • 作者简介:刘亚铭, 硕士, 主要从事微藻功能基因组学研究, E-mail: ymliu@yic.ac.cn
  • 基金资助:
    国家重点研发计划项目（2016YFB0601001）;中国科学院科技服务网络计划项目（KFJ-STS-ZDTP-023）

Genome-wide analysis of putative sugar transporter proteins in eukaryotic microalgae

  1. 1． Key Laboratory of Coastal Biology and Bioresource Utilization， Yantai Institute of Costal Zone Research，Chinese Academy of Sciences， Yantai 264003; 2． University of Chinese Academy of Sciences， Beijing 101418; 3. Biotechnology Research Center， Shandong Academy of Agricultural Sciences, Jinan 250100; 4. Shandong Provincial Key Laboratory of Crop Genetic Improvement of Ecology and Physiology, Jinan 250100; 
    5. Institute of Molecular Agriculture＆ Bioenergy, Shanxi Agricultural University, Taigu 030801, China
  • Online:2019-10-18 Published:2019-10-11

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摘要： 糖转运蛋白是一种位于细胞膜上的重要载体蛋白，负责将胞外的糖类物质转运至细胞内供细胞代谢利用，除了转运功能外，糖转运蛋白还可以作为糖传感器在真核微藻、哺乳动物和高等植物中发挥重要作用。以真核微藻基因组数据为基础，在基因组水平对糖转运蛋白基因的分布、结构和进化规律进行了系统的研究。对测序完成的28株真核微藻糖转运蛋白家族进行了比较基因组学分析，从中发现了70个假定的糖转运蛋白序列，即为9个HUP1，39个HUP2和22个HUP3类型的糖转运蛋白基因。初步推断真核微藻的糖转运蛋白基因是细菌起源的。建立了微藻糖转运蛋白基因-结构-功能的框架结构，对之后构建优良藻株具有重要的理论和现实意义。

关键词: font-size:medium, ">真核微藻；糖转运蛋白；比较基因组学

Abstract: Sugar transporter proteins are located in the cell membrane and are a group of important transmembrane proteins. Sugar transporter proteins transport carbohydrate from extracellular to intracellular for the use of cells. Sugar transporter proteins, as sugar sensors, play an important role in eukaryotic microalgae, breast-feeding animals and higher plants. In this study, comparative genomics analyses were applied to study sugar transporter proteins and to explore their distribution, classification, phylogeny, evolution and structure in eukaryotic microalgae. Twenty-eight eukaryotic microalgae genomes were examined for putative genes of sugar transporter proteins and 70 putative sugar transporter protein sequences were found, which were 9 types of HUP1， 39 types of HUP2 and 22 types of HUP3. Sugar transporter genes of eukaryotic microalgae were origin of bacterium. In this study, a general framework of the sequence-structure-function connections of the sugar transporter genes was revealed.

Key words: eukaryotic microalgae, sugar transporter proteins, comparative genomics

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