生物学杂志

生物学杂志 ›› 2025, Vol. 42 ›› Issue (4): 113-.doi: 10.3969/j.issn.2095-1736.2025.04.113

• 综述与专论 • 上一篇    下一篇

桔青霉素毒性机制及其衍生产物活性研究进展

杜鹏飞1， 汪凤臣2， 盛韵脂1， 王君涛1， 张　芬1， 彭　浩1， 冯自立1,3,4,5   

  1. 1. 陕西理工大学 生物科学与工程学院， 汉中 723000； 2. 陕西萃程生物医药科技有限公司， 汉中
    723000； 3. 秦巴生物资源与生态环境省部共建国家重点实验室（培育）， 汉中 723000； 4. 陕西省资源
    生物重点实验室， 汉中 723000； 5. 陕西省天然活性产物产业化工程技术研究中心， 汉中 723000
  • 出版日期:2025-08-18 发布日期:2025-08-14
  • 通讯作者: 冯自立, 博士, 教授, 研究方向为天然产物化学, E-mail：fengzili@snut.edu.cn
  • 作者简介:杜鹏飞, 硕士研究生, 研究方向为天然药物生物技术, E-mail：19829073668@163.com
  • 基金资助:
    秦巴生物资源与生态环境重点实验室（培育）“市校共建”科研专项(SXZC-2302)；陕西省重点研发计划项目(2022SF-406)

Research progress on toxicity of citrinin and pharmacological effects of its derivatives

DU Pengfei1, WANG Fengchen2, SHENG Yunzhi1, WANG Juntao1, ZHANG Fen1,PENG Hao1, FENG Zili1,3,4,5   

  1. 1. School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China;
    2. Shaanxi Cuicheng Biomedical Technology Co. Ltd., Hanzhong 723000, China; 3. Qinba Biological Resources
    and Ecological Environment Provincial and Ministry Co-Constructed State Key Laboratory(Cultivation),
    Hanzhong 723000, China; 4. Shaanxi Provincial Key Laboratory of Resources and Biology, Hanzhong 723000, China;
    5. Shaanxi Natural Active Products Industrialization Engineering Technology Research Center, Hanzhong 723000, China
  • Online:2025-08-18 Published:2025-08-14

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摘要： 回顾桔青霉素的发展历程，简述桔青霉素的理化性质及毒性，分析桔青霉素的毒性机制和作用靶点。综述桔青霉素的衍生产物，并分析其生物活性及作用机制，简述桔青霉素衍生产物的合成过程。得出桔青霉素通过干预细胞中的重要介质和信号通路产生作用，对其进行结构修饰得到的衍生产物可以在不影响生物活性的情况下有效降低毒性。后续研究可以考虑继续对桔青霉素的结构进行修饰或研究纳米载药技术直接将药物送达患处，避免药物代谢丧失活性，减少药物对正常细胞的影响。

关键词: 桔青霉素, 毒理机制, 抗肿瘤, 抗菌, 神经保护

Abstract: The development history of citrinin was reviewed, the physicochemical properties and toxicity of citrinin were briefly described, and the toxic mechanism and the target of citrinin were analyzed. The derivatives of citrinin were reviewed, and its biological activity and mechanism of action were analyzed. The synthesis process of citrinin derivatives was briefly described. It is concluded that citrinin acts by interfering with important media and signaling pathways in cells, and the derivatives obtained by structural modification can effectively reduce toxicity without affecting biological activity. Subsequent studies may consider continuing to modify the structure of citrinin or studying nano-drug delivery technology to deliver the drug directly to the affected area, avoiding the loss of drug metabolic activity and reducing the impact of the drug on normal cells.

Key words: citrinin, toxicological mechanism, antitumor, antibiosis, neuroprotection

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