生物学杂志

生物学杂志 ›› 2025, Vol. 42 ›› Issue (4): 109-.doi: 10.3969/j.issn.2095-1736.2025.04.109

• 综述与专论 • 上一篇    下一篇

结核分枝杆菌诱导宿主HIF-1α通路活化在免疫调控中的作用

井钦伟1， 朱应鹏2， 周　璐2， 陈　祥1,2， 徐正中1,2， 焦新安1,2   

  1. 1. 扬州大学 江苏省人兽共患病学重点实验室 江苏省动物重要疫病与人兽共患病防控协同创新中心，
    扬州 225009； 2. 扬州大学 农业农村部农产品质量安全生物性危害因子（动物源）控制重点实验室，
    扬州 225009
  • 出版日期:2025-08-18 发布日期:2025-08-14
  • 通讯作者: 徐正中，博士，副教授，研究方向为微生物与免疫学，E-mail:zzxu@yzu.edu.cn；焦新安，博士，教授，研究方向为人兽共患病学，E-mail:jiao@yzu.edu.cn；徐正中和焦新安为共同通信作者
  • 作者简介:井钦伟，硕士，研究方向为预防兽医学，E-mail:2997835098@qq.com
  • 基金资助:
    国家重点研发计划项目（2021YFD1800403）； 江苏省农业科技自主创新资金项目\[CX（21）1004\]； 江苏省重点研发计划项目（现代农业）（BE2021331）； 高等学校学科创新引智计划项目（D18007）； 优势学科建设工程项目（PAPD）

The role of immune regulation in inducing host HIF-1α pathway activation during Mycobacterium tuberculosis infection

JING Qinwei1, ZHU Yingpeng2, ZHOU Lu2, CHEN Xiang1,2, XU Zhengzhong1,2, JIAO Xin ’an1,2   

  1. 1. Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal
    Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China；2. Key Laboratory of Prevention and
    Control of Biologial Hazard Factors (Animal Origin) for Agriood Safery and Quality, MOA of China,
    Yangzhou University, Yangzhou 225009, China
  • Online:2025-08-18 Published:2025-08-14

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摘要： 缺氧诱导因子(hypoxia-inducible factor-1α, HIF-1α)是一种广泛存在于体内的转录因子，在缺氧状态下发挥其调控作用，HIF-1α及其信号通路的激活可以促进细胞存活和增加对损伤性刺激的保护作用。结核分枝杆菌是一种极具传染性的胞内感染型细菌，其感染要面临低氧、一氧化氮和营养缺乏等逆境，缺氧时，HIF-1α通过影响巨噬细胞内的能量代谢途径来调控细胞对结核分枝杆菌的免疫应答，在巨噬细胞抗结核免疫中起着重要作用。旨在总结结核分枝杆菌诱导宿主HIF-1α通路活化在免疫调控中的作用，为结核分枝杆菌致病机制研究和疫苗研发提供参考。

关键词: 结核分枝杆菌, 宿主细胞, HIF-1α通路, 免疫调控, 免疫应答

Abstract: Hypoxia-inducible factor-1α (HIF-1α) is a widespread transcription factor in the body that exerts its regulatory role in hypoxia, and activation of HIF-1α and its signaling pathway promotes cell survival and increases protection against damaging stimuli.Mycobacterium tuberculosisis a highly infectious intracellular infectious bacterium, and its infection is exposed to adversities such as hypoxia, nitric oxide, and nutrient deficiencies. During hypoxia, HIF-1α regulates the cellular immune response toMycobacterium tuberculosisby affecting energy metabolism pathways within the macrophage, and it plays an important role in macrophage anti-tuberculosis immunity. The aim of this paper was to summarize the role ofM. tuberculosis-induced activation of the host HIF-1α pathway in immune regulation, and to provide a reference for the study of the pathogenic mechanism ofM. tuberculosisand vaccine development.

Key words: Mycobacterium tuberculosis, host cell, HIF-1α pathway, immunoregulation, immune response

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