生物学杂志

生物学杂志 ›› 2024, Vol. 41 ›› Issue (4): 94-.doi: 10.3969/j.issn.2095-1736.2024.04.094

• 综述与专论 • 上一篇    下一篇

认知功能障碍：运动、孤独症和脑源性神经营养因子的相互作用

刘　纽1,2， 熊　信1， 薛亚奇1， 王世娇1， 朱　岩1， 甄志平1   

  1. 1. 北京师范大学 体育与运动学院， 北京 100875； 2. 渭南师范学院 体育学院， 渭南 714099
  • 出版日期:2024-08-18 发布日期:2024-08-14
  • 通讯作者: 甄志平，教授，研究方向为运动与健康促进，E-mail:zzpxt@bnu.edu.cn；朱岩，博士，研究方向为运动与健康促进，E-mail:zhy0009@163.com;甄志平和朱岩为共同通信作者
  • 作者简介:刘纽，博士，研究方向为运动与健康促进，E-mail:liusnnu@163.com
  • 基金资助:
    北京市自然科学基金项目（No.7232239）； 陕西省社会科学基金项目（No.2023Q001）； 陕西省高校科技协会青年人才基金项目（No.2021209）； 陕西省体育局常规项目（No.2023009）

The hippocampal cognition dysfunction: interactions among exercise, autism spectrum disorder, and BDNF

LIU Niu1,2, XIONG Xin1, XUE Yaqi1, WANG Shijiao1, ZHU Yan1, ZHEN Zhiping1   

  1. 1. College of P.E and Sports, Beijing Normal University, Beijing 100875, China;
    2. College of Physical Education, Weinan Normal University, Weinan 714099, China
  • Online:2024-08-18 Published:2024-08-14

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摘要： 综述脑源性神经营养因子（Brain-derived neurotrophic factor，BDNF）在运动改善孤独症谱系障碍（Autism spectrum disorder，ASD）海马认知功能中的潜在作用。从BDNF的生物功能和参与SIRT1-PGC1a/FNDC5/Src/PLC-γ1、Ras/MAPK、PI3K/Akt信号通路，ASD患者认知功能相关的脑区改变以及BDNF在ASD不同病理下的表达调控等方面阐述其在促进神经元突触可塑性，提高学习记忆能力，最终改善海马认知功能方面的作用，进一步探讨BDNF在运动改善ASD海马认知功能中可能扮演的重要调控作用，为理解运动通过诱导BDNF表达，改善ASD海马认知功能间复杂的因果关系提供新的视角。最后展望以BDNF为靶点为孤独症疾病临床诊断提供可能的生物学标志物和药物开发提供广阔前景，为运动改善ASD的临床治疗和运动康复提供理论依据和新思路。

关键词: 运动, 脑源性神经营养因子, 孤独症谱系功能障碍, 认知功能, Val66Met

Abstract: In this work, the research progress of brain-derived neurotrophic factor (BDNF) in exercise to improve cognitive dysfunction in autism spectrum disorder (ASD) was reviewed. It focused on the biological functions of BDNF and its involvement in the upstream SIRT1-PGC1a/FNDC5 pathway and downstream Src/PLC-γ1, Ras/MAPK, and PI3K/Akt signaling pathways, alterations in brain regions associated with cognitive function in ASD patients, as well as the mechanisms of BDNF expression and regulation in different pathological biological models of ASD. The paper elaborated on the potential role of BDNF in improving synaptic plasticity, learning and memory abilities, and ultimately cognitive functions of the hippocampus in the brain. In this way, the role of BDNF in promoting neuronal synaptic plasticity, improving learning and memory abilities, and ultimately improving cognitive functions in the brain could be explored, and the regulation of BDNF expression might play an important role in improving hippocampal cognitive functions in patients with ASD, which might provide a new perspective for understanding the complex causal relationship between down-regulation of BDNF expression and the improvement of hippocampal cognitive functions of patients with autism through exercise. It would provide a new perspective for understanding the complex causal relationship between BDNF expression and the improvement of hippocampal cognitive function in autistic patients through exercise. Finally, it was expected that the targeting of BDNF will provide a broad prospect for the development of biomarkers and drugs for the clinical diagnosis of autism, a strong theoretical basis for the clinical treatment of ASD, and new ideas and theoretical foundations for exercise rehabilitation.

Key words: exercise, brain-derived neurotrophic factor, autism spectrum disorder, cognition function, Val66Met

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