生物学杂志

生物学杂志 ›› 2021, Vol. 38 ›› Issue (5): 86-.doi: 10.3969/j.issn. 2095-1736.2021.05.086

• 综述与专论 • 上一篇    下一篇

土贝母抗肿瘤作用研究进展

  

  1. 西南交通大学 生命科学与工程学院, 成都 610031
  • 出版日期:2021-10-18 发布日期:2021-10-21
  • 通讯作者: 黄新河，博士，副教授，衰老生物学及衰老药物学，E-mail：xinhehuang@swjtu.edu.cn
  • 作者简介:杨志华，硕士研究生，研究方向为肿瘤药物学，E-mail: yangzh402@qq.com
  • 基金资助:
    四川省千人计划项目（No.1060）；四川省重点研发项目（No.2018SZ0061）

Research progress on the anti-tumor function of tubeimosides

  1. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
  • Online:2021-10-18 Published:2021-10-21

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摘要： 天然产物是抗癌药物的重要来源，土贝母（tubeimosides，TBMs）为葫芦科贝母属天然产物，具有重要的药用价值，已被广泛用于包括癌症在内的多种疾病的预防和治疗。土贝母主要活性成分是皂苷类，迄今已有16种皂苷被分离出来，研究最多的是土贝母苷甲、乙、丙(tubeimoside I，II，Ⅲ），近年研究表明土贝母在癌变不同阶段均表现出抗癌活性。土贝母的抗癌机制包括抑制癌细胞生长和增殖、诱导癌细胞分化和凋亡、诱导细胞自噬、抑制肿瘤细胞血管生成、抑制细胞侵袭和转移、抑制炎症反应等。结合课题组研究数据，系统总结了土贝母抗肿瘤作用及临床前研究的最新信息，分析其潜在的抗癌分子机制，并探讨土贝母在癌症预防和治疗中的应用前景，以期为土贝母的进一步开发利用提供基础和数据。

关键词: 土贝母, 癌症, 抗肿瘤, 分子机制

Abstract: Natural products are important sources of anti-tumor drugs. As a natural product of the cucurbitaceae fritillary family, tubeimosides (TBMs) has important medicinal values and has been widely used in the prevention and treatment of many diseases, including cancer. The main active ingredients of TBMs are saponins, and 16 saponins have been isolated so far, of which, TBM I, II and III are the most studied active ingredients. Recent studies have shown that TBMs vulgaris have anti-tumor activity in different stages of canceration. The anti-tumor mechanisms of TBMs include inhibiting the growth and proliferation of cancer cells, inducing cancer cell differentiation, apoptosis, autophagy, inhibiting tumor cell angiogenesis, invasion and metastasis, inhibiting inflammation, and so on. This review summarized the latest information on the anti-tumor effect and preclinical research of TBMs and explored the application prospects of TBMs in cancer prevention and treatment. It may provide a foundation for the further development and utilization of TBMs and TBMs-related medicines.

Key words: tubeimosides, cancer, anti-tumor, molecular mechanism

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