生物学杂志

• 综述与专论 • 上一篇    下一篇

白细胞介素21抗肿瘤作用研究进展

  

  1. 江苏大学 生命科学研究院, 镇江 212013
  • 出版日期:2019-04-18 发布日期:2019-04-18
  • 通讯作者: 施海峰,教授,博士生导师,研究方向为细胞生物学, E-mail:shihf@ujs.edu.cn
  • 作者简介:牟春燕,在读硕士研究生,研究方向为生物化学与分子生物学,E-mail:mouchunyan@163.com
  • 基金资助:
    国家自然科学基金项目(No.31600952、31301919);江苏大学杰出学者创业研究基金(No.5501330001)

Research progress of antitumor effect of interleukin-21

  1. Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China
  • Online:2019-04-18 Published:2019-04-18

摘要: 白细胞介素-21(IL-21)是IL-2细胞因子家族成员,主要是由活化的CD4+T细胞产生,对淋巴细胞和髓样细胞具有广泛的生物作用。IL-21从2000年发现至今,其生物学活性和介导的细胞应答免疫机制的研究已经取得了重大进展,特别是抑制血液恶性肿瘤的机制。临床研究显示外源性IL-21可诱导表达IL-21R的B细胞非霍奇金淋巴瘤(NHL)直接凋亡,使其成为具有潜力的抗淋巴瘤治疗新策略。IL-21的抗肿瘤效应主要是通过介导NK细胞和CD4+/CD8+T细胞的杀伤活性实现的。概述了IL-21蛋白的特征、功能及其抗肿瘤方面的临床实验,并且阐述了IL-21与CAR-T细胞和单克隆抗体联用的效果。

关键词: 白细胞介素21, 抗肿瘤作用, 细胞因子

Abstract: Interleukin-21 (IL-21), a member of the IL-2 cytokine family, is predominantly produced by activated CD4+T cells and has a variety of biological effects on lymphocytes and myeloid cells. Since its discovery in 2000, tremendous progress has been made to elucidate IL-21′s induced cellular immune response, especially in the inhibition of hematological malignancies. Preclinical studies have shown that exogenous IL-21 induced the direct apoptosis of B-cell non-Hodgkin lymphoma (NHL) B-cell with expression of IL-21R, making it a potential new strategy for anti-lymphoma therapy. The antitumor effect of IL-21 is mainly mediated through the cytotoxic activity of NK cells and CD4+/ CD8+T cells. This review provides an overview of the biological structure and function of IL-21 and its anti-tumor clinical trials, and illustrates the efficacy of IL-21 in combination with CAR-T cells and monoclonal antibodies.

Key words: IL-21, anti-tumor function, cytokine

中图分类号: