生物学杂志

生物学杂志 ›› 2024, Vol. 41 ›› Issue (4): 37-.doi: 10.3969/j.issn.2095-1736.2024.04.037

• 研究报告 • 上一篇    下一篇

金针菇基医用复合敷料的制备与研究

王应雪1， 谭文丽2， 季　巧1， 杨　凡1， 文馨可1， 袁久刚1   

  1. 1. 江南大学 纺织科学与工程学院， 无锡 214122; 2. 江苏中纺联检验技术服务有限公司， 苏州 215100
  • 出版日期:2024-08-18 发布日期:2024-08-14
  • 通讯作者: 袁久刚，博士，副教授，研究方向为天然材料的加工及改性，E-mail:jiugangyuan@163.com
  • 作者简介:王应雪，硕士研究生，研究方向为真菌复合材料，E-mail:wangyingxue0517@163.com
  • 基金资助:
    国家自然科学基金项目（31771039）

Preparation and study of Flammulina velutipes-based medical composite dressing

WANG Yingxue1, TAN Wenli2, JI Qiao1,YANG Fan1, WEN Xinke1, YUAN Jiugang1   

  1. 1. College of Textile Science and Engineering, Jiangnan University, Wuxi 214122, China;
    2. Jiangsu Textile Union Inspection Technology Service Limited Company, Suzhou 215100, China
  • Online:2024-08-18 Published:2024-08-14

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摘要： 以多糖提取后的富含几丁质和葡聚糖的金针菇样品为原料，通过冻干法制备金针菇基医用复合敷料。分别采用红外光谱、扫描电镜对材料的形貌及结构进行表征，并测试其抗菌性能、力学性能、吸水保水性能、水蒸气透过率、止血性能、降解性能以及细胞毒性等。结果表明：金针菇样品具有较好的抑菌性能，大肠杆菌抑菌率可达98.83%，金黄色葡萄球菌抑菌率约为88.78%；金针菇基复合敷料的物理性能良好，手感柔软，拉伸应力可达15.20 MPa，断裂伸长率84.11%，吸水保水性优良，水蒸气透过率可达2500 g/(m2·d)，体外凝血指数最佳为0.32，而且该敷料无毒无害，丢弃后35 d的土壤降解率即可达到79.79%。结果表明，金针菇基复合敷料具有较好的医用潜力，可用于伤口敷料和组织工程领域。研究对促进真菌多糖提取副产物的利用，提升金针菇附加值具有重要意义。

关键词: 真菌复合材料, 医用敷料, 金针菇, 几丁质, 明胶

Abstract: NewFlammulina velutipes-based composite material was prepared by freeze-drying method withFlammulina velutipesrich in chitin and dextran as raw material after extraction of polysaccharides. TheFlammulina velutipes-based composite was analyzed by infrared spectrum and scanning electron microscope. The samples characteristics such as anti-microbial properties, mechanical properties, swelling property, water vapor permeability, coagulation performancein vitro, degradability and cytotoxicity were assayed. Results showed thatFlammulina velutipessamples had excellent antibacterial properties, and the bacteriostatic rates ofEscherichia coliandStaphylococcus aureuswere 98.51% and 88.18% respectively.Flammulina velutipes-based composite dressing had excellent physical properties and high softness, and had excellent water absorption and water retention. Its breaking strength was 15.20 MPa and elongation was 84.11%. Its water vapor permeability number reached 2500 g/(m2·d), the coagulation indexin vitrowas 0.3. Moreover, the dressing was non-toxic and harmless, and the soil degradation rate could reach 79.79% after 35 days of discarding. This study demonstrated thatFlammulina velutipes-based composite dressing had excellent medical potential and could be used in wound dressing and tissue engineering. This study was of great significance to promote the utilization of by-products of fungal polysaccharide extraction and enhance the added value ofFlammulina velutipes.

Key words: fungal composite materials, medical dressing;Flammulina velutipes, chitin, gelatin

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