In order to adapt to the innovation and development of higher education, the educational and teaching rules of setup bioengineering specialty (bio-pharmaceutical direction) for students in normal universities are actively explored. The "a three-dimensional teaching mode of integration with three levels through four steps" cultivation is constructed by reconstructing creative and applied experimental instructor on basis of meeting the demands of the pharmaceutical and other related industries and companies as well as postgraduate studies of research institutes and colleges. A cultivating system with prominent professional feature, independent and comprehensive system, scientific management and the prominently subject status of student is perfectly formed. These solutions could perfectly solve the disconnection problem between the theoretical basis and practice in the scientific research and the application in the field of bio-pharmaceutical and medicine. This cultivation is focused on forming the ability of practice and innovation for the bio-pharmaceutical students, and improving their comprehensive application. These initiatives promote the two aspects of students′ development in further scientific investigation and formal employment development, adapting to the requirements of scientific research of institutes and the pharmaceutical and other related industries.