生物学杂志

生物学杂志 ›› 2022, Vol. 39 ›› Issue (4): 98-.doi: 10.3969/j.issn.2095-1736.2022.04.098

• 综述与专论 • 上一篇    下一篇

微生态食品调节肠道菌群抗抑郁研究进展

  

  1. 1. 华南农业大学 食品学院， 广州 510640； 2. 华南农业大学 林学与风景园林学院， 广州 510640；
    3. 健码制药（广东）有限公司， 广州 510850； 4. 广东省微生态制剂工程技术研究中心， 广州 510640
  • 出版日期:2022-08-18 发布日期:2022-08-15
  • 通讯作者: 林俊芳，研究员，博士，研究方向为精准营养与健康，E-mail: linjf@scau.edu.cn
  • 作者简介:陈乐涛，硕士，研究方向为微生态制剂创制，E-mail: chenlet@yeah.net
  • 基金资助:
    国家自然科学基金项目（32072646）； 健码制药（广东）有限公司资助项目（HXKJH720201125）

Research progress of microecological food in improving depression by regulating the Gut microbiota #br#

  1. 1. College of Food Science, South China Agricultural University, Guangzhou 510640, China; 2. College of Forestry
    and Landscape Architecture, South China Agricultural University, Guangzhou 510640, China; 3. Health-decode
    Pharmacy (Guangdong) Co., Ltd., Guangzhou 510850, China; 4. Research Center for Micro-Ecological Agent
    Engineering and Technology of Guangdong Province, Guangzhou 510640, China
  • Online:2022-08-18 Published:2022-08-15

PDF (PC)

46

摘要： 介绍肠道菌群与中枢神经系统存在双向交流以及这种交流与抑郁症发生和治疗的相关性。探讨调节肠道菌群影响神经中枢功能及肠道菌群通过炎症反应、肠道菌群代谢物、HPA轴和迷走神经等方式影响抑郁症。基于肠道菌群-肠-脑轴理论，分析益生菌、益生元和食药物质等3种微生态食品通过调节肠道菌群而改善抑郁症的作用机制，并且针对现有研究提出微生态食品抗抑郁作用的挑战与机遇，以期给予后续研究提供新的方向。

关键词: 抑郁症, 肠道菌群-肠-脑轴, 益生菌, 益生元, 食药物质

Abstract: The study found the presence of bidirectional communication networks between the gut microbiota and the central nervous system (CNS), which is associated with the development and treatment of depression. It is an accepted fact that the function of the CNS is affected by regulating the gut microbiome. The gut microbiome can affect depression through inflammation, the gut microbiome metabolites, HPA axis and vagus nerve. Based on the theory of the gut microbiome-gut -brain axis, the mechanism of three kinds of microecological foods including probiotics, prebiotics and food-medicine homologous traditional Chinese medicine in improving depression by regulating intestinal flora was analyzed, and according to the existing research, the challenges and opportunities of the antidepressant effect of microecological food were put forward, so as to provide a new direction for follow-up research.

Key words: depression, the gut microbiome-gut-brain axis, probiotics, prebiotics, food-medicine homologous traditional Chinese medicine

中图分类号: