生物学杂志 ›› 2021, Vol. 38 ›› Issue (6): 99-.doi: 10.3969/j.issn.2095-1736.2021.06.099

• 综述与专论 • 上一篇    下一篇

非洲猪瘟病毒及其疫苗研究进展

  

  1. 1.扬州大学 江苏省人兽共患病学重点实验室,扬州 225009;
    2. 扬州大学 江苏高校动物重要疫病与人兽共患病防控协同创新中心,扬州 225009;
    3. 扬州大学 农业农村部农产品质量安全生物性危害因子(动物源)控制重点实验室,扬州 225009;
    4. 扬州大学 农业与农产品安全国际合作联合实验室,扬州 225009)
  • 出版日期:2021-12-18 发布日期:2021-12-15
  • 通讯作者: 潘志明,博士,教授,研究方向为动物疫病防控及免疫机理研究,E-mail: zmpan@yzu.edu.cn
  • 作者简介:黄霞,硕士研究生,研究方向为非洲猪瘟疫苗,E-mail: 1551408991@qq.com
  • 基金资助:
    江苏省重点研发计划(现代农业)项目(BE2020398);农业农村部农业行业管理业务经费项目(16190023);扬州大学科技创新团队项目(2016);江苏省高校优势学科建设工程资助项目(PAPD)

Research progress on African swine fever virus and its vaccines

  1. 1.Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou 225009, China;
     2. Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou University, Yangzhou 225009, China;
    3. Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou 225009, China;
      4. Joint International Research Laboratory of Agriculture and Agri-product Safety of the Ministry of Education,
    Yangzhou University, Yangzhou 225009, Chin
  • Online:2021-12-18 Published:2021-12-15

摘要: 以非洲猪瘟病毒(African swine fever virus,ASFV)为研究对象,分别从病毒的结构、感染与免疫机制、传播途径、致病性等方面总结了ASFV的病原学特性;全面分析了非洲猪瘟(African swine fever,ASF)疫苗的研究现状:灭活疫苗无法提供保护,亚单位疫苗、核酸疫苗以及病毒载体疫苗通常提供部分保护,减毒活疫苗可提供同源保护且最有潜力应用于临床。在此基础上,发现ASFV的复杂性以及免疫生物学特征的不确定性影响疫苗的研发进度,提出中国ASF疫苗研发所面临的挑战,以期为疫苗的研发提供新的认识和途径。

关键词: 非洲猪瘟, 病毒, 感染, 免疫, 疫苗

Abstract: Taking African swine fever virus (ASFV) as the research object, pathogenic characteristics of ASFV including virus structure, infection and immune mechanism, transmission route, and pathogenicity were summarized. Meanwhile, the research status of African swine fever (ASF) vaccines was analyzed: inactivated vaccines cannot provide protection; subunit vaccines, nucleic acid vaccines and viral vector vaccines usually provide partial protection; live attenuated vaccines can provide homologous protection and are most potential for clinical application. On this basis, it was found that the complexity of ASFV and the uncertainty of immunobiological characteristics affect the progress of vaccine research. And the challenges in development of ASF vaccines faced by China were put forward to providing a new understanding and approach for vaccine development.

Key words: African swine fever, virus, infection, immunity, vaccine

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