生物学杂志

生物学杂志 ›› 2021, Vol. 38 ›› Issue (2): 95-.doi: 10.3969/j.issn.2095-1736.2021.02.095

• 综述与专论 • 上一篇    下一篇

基因工程抗体及其在识别小分子中的应用

  

  1. 1.江苏大学生命科学研究院，镇江212013；2.江苏维尔生物科技有限公司，常州213003
  • 出版日期:2021-04-18 发布日期:2021-04-25
  • 通讯作者: 吕 鹏，博士，助理研究员，研究方向为基因工程抗体筛选及分子诊断， E⁃mail：penglu@ujs.edu.cn
  • 作者简介:王沁芸，硕士，研究方向为基因工程抗体及其应用， E⁃mail：2211717031@stmail.ujs.edu.cn
  • 基金资助:
    江苏省重点研发社会发展—面上项目（BE2017651）

Genetically engineered antibodies and their applications in recognizing small molecules

  1. 1. Institute of Life Sciences，Jiangsu University，Zhenjiang 212013，China；2. Jiangsu Well Biotech Co.，Ltd.，Changzhou 213003，China
  • Online:2021-04-18 Published:2021-04-25

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摘要： 对基因工程抗体的种类以及筛选制备进行详细介绍，并对目前其在小分子识别中的研究进行梳理总结，分析基因工程抗体在识别小分子方面的优势，对应用中存在的问题进行讨论，希望对基因工程抗体在小分子识别中的进一步应用和产品研发提供一些思路。

关键词: 基因工程抗体, 小分子, 抗体库技术, 体外展示技术, 检测

Abstract: The types of genetically engineered antibodies with preparation and selection were introduced. Current researches on small molecule detection were also summarized. The advantages of genetically engineered antibodies in recognizing small molecules were analyzed and the problems in application were discussed to provide some ideas for the further adhibition and product development.

Key words: genetically engineered antibody, small molecule, antibody library technique, in vitrodisplay technology, detection

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