生物学杂志

生物学杂志

• 综述与专论 • 上一篇    下一篇

镉导致高血压发生机制的研究进展

  

  1. 1. 江苏大学 生命科学研究院， 镇江 212013； 2. 皖西学院 生物与制药工程学院 中药研究与开发工程技术研究中心， 六安 237012
  • 出版日期:2017-08-18 发布日期:2017-08-18
  • 通讯作者: 施海峰，教授，博士生导师，研究方向为铁代谢、重金属毒性, E-mail：shihf@ujs.edu.cn
  • 作者简介:季星岐，硕士研究生，生物化学与分子生物学,E-mali：olivia_jxq@sina.com
  • 基金资助:
    国家自然科学基金项目（No.31271272、31301919）；江苏省自然科学基金（BK20130506）；安徽省自然科学基金（1508085MH203）；安徽省高等学校省级自然科学基金项目（KJ2011A270、KJ2013A265）；江苏省六大人才高峰项目“人细胞铁代谢紊乱与人的相关疾病”

Research progress in mechanisms of cadmium induced hypertension

  1. 1. Institute of Life Sciences, Jiangsu University, Zhenjiang 212013; 2. Engineering Technology Research Center of Research and Development of Traditional Chinese Medicine, College of Biological and Pharmaceutical Engineering, West Anhui University, Lu′an 237012, China
  • Online:2017-08-18 Published:2017-08-18

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摘要： 镉具有很强的生物毒性，它可通过吸烟、饮食、呼吸等方式进入人体，并在人体内积累，造成机体损伤。镉在人体内积累后不但能导致骨骼畸形、肾脏损伤和癌症的发生，而且还能导致机体脂代谢紊乱，而脂代谢紊乱会导致心脑血管疾病的发生。近年来，有越来越多的研究结果发现镉能诱导哺乳动物产生心脏病、高血压等疾病，其分子机制包括镉产生大量自由基、镉抑制Na+/K+泵活性、镉影响VE-cadherin的功能等。综述了镉导致心脑血管疾病发生机制的研究进展。

关键词: 镉, 心脑血管疾病, VE-cadherin, 自由基, Na+/K+泵

Abstract: Cadmium has strong biological toxicity. It could be absorbed by smoking, dietary and inhalation. Cadmium could lead to series damage to mammalian, including bone misshapen, kidney injury and cancer; it can also lead to abnormal lipid metabolism. In recent years, many researchers found that cadmium could lead to cardiovescular diseases in mammalians, such as heart attack, hypertension and so on，however, the mechanism is still unknown. The mechanism of this phenomenon could be the result of ROS(Reactive oxygen species) production, Na+/K+ ATPase activity inhibition and impaired VE-cadherin function. Here, we discussed the research progress in mechanisms of cadmium induced hypertension.

Key words: cadmium, cardiovescular diseases, VE-cadherin, ROS, Na+/K+ ATPase