生物学杂志

生物学杂志 ›› 2026, Vol. 43 ›› Issue (5): 126-.doi: 10.3969/j.issn.2095-1736.2026.05.126

• 教学研究 • 上一篇    

童第周核质互作理论虚拟仿真实验课程及其智能体的创建

时永香1， 刘博洋2， 张传鑫2， 徐宇鑫2， 陈广安3， 吴克良1,2   

  1. 1. 山东大学 生命科学学院， 青岛 266237； 2. 山东大学妇儿与生殖健康研究院， 济南 250012；
    3. 山东大学 海洋研究院， 青岛 266237
  • 出版日期:2026-10-18 发布日期:2026-10-20
  • 通讯作者: 吴克良，博士，教授，研究方向为细胞生物学与胚胎学，E-mail:wukeliang_527@163.com
  • 作者简介:时永香，博士，副教授，研究方向为发育免疫学和生命教育，E-mail:shiyx@sdu.edu.cn
  • 基金资助:
    山东大学教育教学综合改革项目（2021Z18， 2023Z20， 2024Z20， 2024Y070， 2023Y244）； 山东大学【研·课程思政建设】工程（第四期）专项（2024， 序号：44）

Creation of the virtual simulation experiment course on Ti-Chou Tung’s nuclear-cytoplasmic interaction theory and its intelligent agent

SHI Yongxiang1, LIU Boyang2, ZHANG Chuanxin2, XU Yuxin2,CHEN Guang’an3, WU Keliang1,2   

  1. 1. School of Life Sciences, Shandong University, Qingdao 266237, China;
    2. Institute of Women, Children and Reproductive Health, Shandong University, Jinan 250012, China;
    3. Institute of Marine Science and Technology, Shandong University, Qingdao 266237, China
  • Online:2026-10-18 Published:2026-10-20

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摘要： 本文介绍以童第周核质互作理论为基础，面向生命科学和新医科，多学科交叉，并与现代教育技术融合的创新教学虚拟仿真实验课程设计与实践——“细胞核移植重编程软件V2.0”的开发与应用及其智能体的创建。此软件系统包含10个子实验；通过三维建模、动态仿真和智能评估技术，完整串联起从实验鼠的准备和处理、以淋巴细胞为核供体、收集M Ⅱ期卵母细胞进行细胞核移植，并最终将重构胚进行输卵管移植的全流程操作。该课程已在线发布并开放课程资源，点击链接（http:∥www.vs.sdu.edu.cn/virexp/xbhyz）即可进入课程。经试用和问卷星反馈，用户认为教学内容符合“两性一度”，教学方法灵活，利于学习者参与，学习兴趣和能力及创新思维等各方面都有所提升。伴有智能体，AI赋能将不断升级，课程为传承经典科学思想和培养前沿生命医学领域创新人才提供示范案例。

关键词: 核质互作理论, 细胞核移植, 重编程, 虚拟仿真, 自主创新

Abstract: This study presented an innovative virtual simulation teaching system—cell nuclear reprogramming software V2.0 and its intelligent agent—developed by integrating Ti-Chou Tung’s nuclear-cytoplasmic interaction theory with multidisciplinary approaches and modern educational technology. The software system comprised 10 sub-experiments. Through 3D modeling, dynamic simulation, and intelligent evaluation technologies, it fully reproduced the entire process of preparing and handling experimental mice, using lymphocytes as nuclear donors, collecting MⅡ stage oocytes for nuclear transfer, and finally transplanting the reconstructed embryos into the oviducts. Currently deployed online (Access: http://www.vs.sdu.edu.cn/virexp/xbhyz), post-implementation surveys via Wenjuanxing confirmed that the course meet the “two properties and one degree” standard, it enhanced learner engagement through flexible pedagogy, and significantly improved students’ interest, competencies, and innovative thinking. An intelligent agent embedded with continuous AI-powered upgrads. This project established a model for preserving foundational scientific theories while cultivating interdisciplinary talent in cutting-edge biomedicine.

Key words: clear cytoplasm interaction theory, cell nuclear transplantation, reprogramming, virtual simulation, independent innovation

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