生物学杂志

生物学杂志 ›› 2023, Vol. 40 ›› Issue (2): 91-.doi: 10.3969/j.issn.2095-1736.2023.02.091

• 综述与专论 • 上一篇    下一篇

非洲猪瘟病毒调控宿主免疫应答机制研究进展

袁　理1,2,3,4， 熊　丹1,2,3,4， 康喜龙1,2,3,4， 潘志明1,2,3,4， 焦新安1,2,3,4   

  1. 1.扬州大学 江苏省人兽共患病学重点实验室，扬州 225009；
    2.江苏省动物重要疫病与人兽共患病防控协同创新中心，扬州 225009；
    3.农业农村部农产品质量安全生物性危害因子（动物源）控制重点实验室，扬州 225009；
    4.教育部农业与农产品安全国际合作联合实验室，扬州 225009
  • 出版日期:2023-04-18 发布日期:2023-04-18
  • 通讯作者: 潘志明，博士，教授，研究方向为动物新型疫苗创制，E-mail: zmpan@yzu.edu.cn
  • 作者简介:袁理，硕士研究生，研究方向为非洲猪瘟病毒免疫逃逸机制，E-mail: 382870570@qq.com
  • 基金资助:
    江苏省重点研发计划（现代农业）重点项目（BE2020398，BE2021331）； 江苏省农业自主创新资金项目（CX(21)2035）； 江苏省高校优势学科建设工程资助项目（PAPD）

Research progress on mechanism of African swine fever virus regulating host immune response

YUAN Li1,2,3,4, XIONG Dan1,2,3,4, KANG Xilong1,2,3,4, PAN Zhiming1,2,3,4, JIAO Xin’an1,2,3,4   

  1. 1.Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou 225009, China; 2.Jiangsu Co-innovation
    Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China;
    3.Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and
    Quality of the Ministry of Agriculture and Rural Affairs of China, Yangzhou 225009, China; 4.Joint International
    Research Laboratory of Agriculture and Agri-product Safety of the Ministry of Education, Yangzhou 225009, China
  • Online:2023-04-18 Published:2023-04-18

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摘要： 非洲猪瘟病毒（African swine fever virus, ASFV）编码多种免疫逃逸蛋白以拮抗宿主免疫应答，造成病毒在宿主体内持续感染。非洲猪瘟（African swine fever, ASF）疫苗研发面临的主要困难是对ASFV的毒力相关基因、致病及免疫调控机制知之甚少。对ASFV入侵机体后的免疫调控机制进行总结，从天然免疫和获得性免疫两个角度分析ASFV免疫调控蛋白的功能：调控机体内炎症与干扰素产生，调控抗原呈递与细胞免疫；并探讨潜在的ASFV新型疫苗候选：重组NH/P68弱毒株、融合蛋白ZPMT、基因缺失毒株ASFV-ΔECM3等。为ASFV致病机制研究和新型疫苗研发提供参考。

关键词: 非洲猪瘟病毒, 免疫调控, 免疫逃逸蛋白, 分子机制, 疫苗研发

Abstract: African swine fever virus (ASFV) encodes a variety of immune escape proteins to antagonize the host immune response, resulting in the persistent infection of the virus in the host. The main difficulty in the development of African swine fever (ASF) vaccine is that little is known about the virulence related genes, pathogenicity and immune regulation mechanism of ASFV. This paper summarized the immune regulation mechanism of African swine fever virus (ASFV) after invading the host. It discussed the specific function of ASFV immune-regulation proteins from the perspective of innate immunity and acquired immunity: regulating inflammation, interferon production, antigen presentation and cellular immunity, and explored potential new vaccine candidates of ASFV: recombinant NH/P68 attenuated strain, new fusion protein ZPMT, gene deletion strain ASFV-ΔECM3, etc, so as to provide reference for the study of ASFV pathogenesis and the development of new vaccines.

Key words: African swine fever virus, immune regulation, immune evasion protein, molecular mechanism, vaccine development

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