生物学杂志 ›› 2022, Vol. 39 ›› Issue (5): 104-.doi: 10.3969/j.issn.2095-1736.2022.05.104

• 综述与专论 • 上一篇    下一篇

病毒侵染过程中肌动蛋白的作用研究进展

  

  1. 扬州大学 生物科学与技术学院, 扬州 225100)
  • 出版日期:2022-10-18 发布日期:2022-10-19
  • 通讯作者: 赵淑玲,博士,副教授,主要研究方向为昆虫病毒和植物病毒,E-mail: slzhao@yzu.edu.cn
  • 作者简介:李杰,硕士,主要研究方向为昆虫病毒,E-mail: 1280032652@qq.com
  • 基金资助:
    国家自然科学基金项目(31600122)

Research progress on role of actin in virus infection

  1. College of Biological Science and Technology, Yangzhou University, Yangzhou 225100, China
  • Online:2022-10-18 Published:2022-10-19

摘要: 从病毒进入、复制、释放以及在细胞间传播等方面概述肌动蛋白在其中的功能,重点介绍在病毒感染的不同阶段病毒招募、诱导肌动蛋白形成的具体过程、途径及作用,探讨病毒调控肌动蛋白细胞骨架重排的分子机制和调节方式。虽然目前对肌动蛋白参与病毒侵入及释放的过程了解较多,但对其参与病毒复制及组装的研究还较少,肌动蛋白调控的分子机制和信号途径还需更深入地研究,以期为进一步阐明病毒侵染的分子机制,发展新的抗病毒策略提供理论依据。

关键词: 肌动蛋白, 病毒, 侵染, 细胞骨架

Abstract: The research progress on the functions of actin in virus entry, replication, release and spread between the cells was summarized, which focused on the specific process and function of virus recruitment and induction of actin formation in different stages of virus infection as well as the molecular mechanism of virus regulating actin rearrangement. Although much is known about the involvement of actin in virus entry and release, there is still less research on its involvement in virus replication and assembly. The molecular mechanism and signal pathway of virus regulating actin need to be further studied in order to clarify the molecular mechanism of virus infection and develop new antiviral strategies.

Key words: actin, virus, infection, cytoskeleton

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