生物学杂志

生物学杂志 ›› 2021, Vol. 38 ›› Issue (5): 105-.doi: 10.3969/j.issn.2095-1736.2021.05.105

• 综述与专论 • 上一篇    下一篇

潘氏细胞为小肠干细胞提供微环境信号因子研究进展

  

  1. 三峡大学 医学院，宜昌 443002
  • 出版日期:2021-10-18 发布日期:2021-10-21
  • 通讯作者: 顿耀艳，博士，副教授，研究方向为肠道相关疾病机制及中药干预，E-mail: dyydxy2004@163.com
  • 作者简介:李艳丽，硕士研究生，主要从事肠道相关疾病机制及中药干预研究，E-mail: 1578182335@qq.com
  • 基金资助:
    国家自然科学基金项目（81873349,81503423,81403307）

Microenvironment signaling factors of intestinal stem cells provided by Paneth cells

  1. Medical College, China Three Gorges University, Yichang 443002, China
  • Online:2021-10-18 Published:2021-10-21

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摘要： 潘氏细胞是重要的微环境信号分子提供者，可为小肠干细胞（intestinal stem cells,ISCs）提供Wnt、Notch、EGF、mTORC1等相关信号因子，维持干细胞的增殖和分化平衡。对潘氏细胞提供ISCs微环境信号因子，以及潘氏细胞相关信号因子变化导致的小肠上皮稳态失调进行概述，旨在为潘氏细胞和ISCs相互作用的研究提供思考，为相关小肠上皮稳态失调提供新的治疗思路。

关键词: 潘氏细胞, 微环境, 小肠干细胞, 信号因子, 小肠上皮稳态

Abstract: The microenvironment composed of cells adjacent to intestinal stem cells （ISCs） is key to the function of ISCs by providing a variety of essential signaling factors that regulate important signaling pathways for proliferation and differentiation in ISCs. Paneth cells are important providers of ISCs microenvironmental signaling molecules, and they can provide Wnt, Notch, EGF, mTORC1 and other related signaling factors for ISCs to maintain the balance of proliferation and differentiation. The signaling factors secreted by the Paneth cell are summarized here, to provide some ideas for the study of interaction between Paneth cells and ISCs, and the treatment of some intestinal epithelial homeostasis disorders.

Key words: Paneth cells, microenvironment, intestinal stem cells, signaling factors, intestinal epithelial homeostasis

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