生物学杂志

生物学杂志

• 综述与专论 • 上一篇    下一篇

IL-33活性调节及在疾病中的调控作用

  

  1. 兰州大学 生命科学学院, 兰州 730000
  • 出版日期:2017-06-18 发布日期:2017-06-18
  • 通讯作者: 吉尚戎，教授,博士,研究方向为蛋白质结构功能及重要蛋白质参与慢性炎症疾病调控的分子机制，E-mail: jsr@lzu.edu.cn
  • 作者简介:刘善辉，博士研究生, 研究方向为蛋白质结构功能与自身免疫疾病，E-mail: liushh2014@lzu.edu.cn; 张世超，博士研究生，研究方向为蛋白质的功能及表达调控，E-mail：zhangshch08@lzu.edu.cn
  • 基金资助:
    中央高校基本科研业务费专项资金(lzujbky-2016-k11)

IL-33:activation, regulation and function

  1. School of Life Sciences, Lanzhou University， Lanzhou 730000, China
  • Online:2017-06-18 Published:2017-06-18

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摘要： IL-33是近期发现的IL-1家族新成员，与传统的细胞因子有所不同，其N端结构域具有核定位信号，具有转录调节活性。IL-33可通过IL-33/ST2L信号途径促进2型免疫反应参与心血管疾病、阿尔茨海默症、癌症、肥胖等多种重大疾病的调节。综述近年IL-33研究进展，阐释不同剪切形式和二硫键分子“开关”对IL-33活性的影响，介绍IL-33/ST2L在一些重大疾病中的调控作用，为后续IL-33在疾病诊断治疗中的应用提供参考。

关键词: IL-1家族, IL-33/ST2L信号, 2型免疫反应, 二硫键

Abstract: IL-33, a novel member of the IL-1 family, mediates its biological effects via the ST2 receptor (also known as IL-1RL1), and initiates a type 2 immune response during cardiovascular disease, Alzheimer′s disease, cancer and obesity. IL-33 is a dual-function protein that act both as a cytokine and as an intracellular nuclear factor. Here, we review the recent advances on how IL-33 activity is regulated by proteolysis and oxidation-driven conformational change of two disulphide bonds formation, and the newly discovered roles of IL-33 in atherosclerosis, obesity, rheumatoid arthritis, and Alzheimer′s disease. IL-33 mobilizes innate immunity and acquires immunity to initiate type-2 immune response by the IL-33/ST2L pathway. Therapeutic strategy targeting IL-33 may be an effective strategy to ameliorate these diseases.

Key words: IL-1 family, IL-33/ST2L signal, type 2 immune response, two disulphide bonds