生物学杂志 ›› 2020, Vol. 37 ›› Issue (5): 103-.doi: 10.3969/j.issn.2095-1736.2020.05.103

• 综述与专论 • 上一篇    下一篇

人生长激素的发展、应用与研究展望

  

  1. 1. 安徽安科生物工程(集团)股份有限公司, 合肥 230088; 2. 安徽省生物研究所, 合肥 230088
  • 出版日期:2020-10-18 发布日期:2020-10-14
  • 通讯作者: 宋礼华,博士研究生,研究员,研究方向为基因工程药物的开发与产业化,E-mail:songlh@ankebio.com
  • 作者简介:卢晨,硕士研究生,工程师,研究方向为基因工程药物研发等工作,E-mail:luchen_1025@163.com
  • 基金资助:
    安徽省科技攻关计划项目(编号:09010301018)

Development, application and research expectationof human growth hormone

  1. 1. Anhui Anke Biotechnology (Group) Co., Ltd, Hefei 230088;     2. The Biology Institute of Anhui Province, Hefei 230088, China
  • Online:2020-10-18 Published:2020-10-14

摘要: 人生长激素(human growth hormone, hGH)是由脑垂体前叶分泌的一种肽类激素,通过GH-IGF-1轴对人体的生长与代谢起重要的调控作用。1958年Raben最早使用垂体源性生长激素(pit-hGH)治疗垂体功能减退症的患儿并取得良好效果。随着分子生物学技术的突破,Goeddel和Seeburg于1979年利用基因重组表达技术成功研制出成本更低安全性更高的重组人生长激素(rhGH)。1985年美国FDA批准了rhGH应用于GHD的患者。如今rhGH的临床应用不仅局限于儿童矮身材的治疗,其在重度烧伤、成人生长激素缺乏症(AGHD)、慢性肾功能不全、辅助生殖、先天性卵巢功能发育不全、呼吸功能衰竭、重症感染以及抗衰老等领域亦有广泛应用。伴随着生长激素生产工艺和制剂剂型的改进以及其作用机制进一步的揭示,该药物有望为人类带来更大福音。

关键词: 人生长激素, 基因重组表达, 儿童矮身材, 成人生长激素缺乏, 重度烧伤

Abstract: Human growth hormone(hGH)is a peptide hormone secreted by the anterior pituitary gland, which plays an important role in regulating the human metabolism and growth via the GH-IGF-1 axis. In 1958, Raben was one of earliest on using pituitary-derived growth hormone(pit-hGH)to treat children with hypopituitarism and got good effect. With the rapid development of molecular biology techniques, Goeddel and Seeburg have developed a lower cost and safer recombinant human growth hormone(rhGH)using gene recombinant expression technology in 1979. In 1985, the FDA approved rhGH for GHD patients. Today, the clinical application of rhGH is not confined to treat children with short statues. It is also widely used in severe burn, adult growth hormone deficiency(AGHD), chronic renal insufficiency, assisted reproductive, congenital hypoplasia of ovary, respiratory failure, severe infection and anti-aging fields. With the improvement of manufacturing processes and dosage form and the further elucidated of metabolic mechanisms, the rhGH is expected to bring more benefits to humankind.

Key words: human growth hormone, gene recombinant expression, children′s short stature, adult growth hormone deficiency, severe burns

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