生物学杂志

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药物成瘾记忆及其神经环路研究进展

  

  1. 1. 云南师范大学 生命科学学院 生物能源持续开发利用教育部工程研究中心和云南省生物质能与环境生物技术重点实验室, 昆明 650500; 2. 云南师范大学 体育学院国家级高原训练实验教学中心, 昆明 650500
  • 出版日期:2018-02-18 发布日期:2018-02-18
  • 通讯作者: 王功伍,博士,副教授,硕士生导师,研究方向为神经生物学,E-mail: waov@tom.com
  • 作者简介:李 平,硕士研究生,研究方向为神经生物学,E-mail: 1173675902@qq.com
  • 基金资助:
    国家自然科学基金项目(31060142);教育部“春晖计划”合作科研项目(Z2011126);云南师范大学生物资源开发与保护“登峰扎根”优秀科研创新团队(2016-15); 云南省科技计划(2014RA010)

Research progress in drug addiction memory and its neural circuitry

  1. 1. Engineering Research Center of Sustainable Development and Utilization of Biomass, Ministry of Education & Key Laboratory of Yunnan for Biomass Energy and Biotechnology of Environment, School of Life Sciences,Yunnan Normal University, Kunming 650500; 2. National Altitude Training Experimental Teaching Demonstrating Center, School of Physical Education, Yunnan Normal University, Kunming 650500, China
  • Online:2018-02-18 Published:2018-02-18

摘要: 药物成瘾严重危害人类健康和社会安全,对成瘾机理和防治方法的研究一直是国内外研究的热点。近年来随着对人和动物详细神经网络的逐步阐明,特别是光遗传学技术的迅速发展和应用,人们已在成瘾相关的脑区及其神经环路研究方面取得了重要进展,确认药物成瘾特别是心理成瘾是一种脑疾病,是一种顽固的病态性记忆(成瘾记忆),因此可采用干扰记忆过程的策略治疗心理成瘾。成瘾记忆涉及多个脑区,这些脑区及其神经环路同样在正常学习和记忆中发挥重要作用。主要对近年来有关药物成瘾记忆及其相关神经环路机制的研究进展作一简要介绍。

关键词: 药物成瘾, 学习和记忆, 神经环路

Abstract: Drug addiction has produced serious impairment on human health and threatens the security and stability of the whole society. Therefore, how to prevent and cure drug addiction and to uncover the working mechanisms are always the hot spots of research at home and abroad. In recent years, the brain neural network of human and animal has been clarified in detail, especially underlying the rapid application of the optogenetics technology. Scientists have made some important progress in drug addiction related brain regions and circuits. The drug addiction, especially the psychological addiction, has been regarded as a brain disease, a pathological, solid memory, or mnemonic disease, which we call addiction memory. Therefore, it would be an efficient strategy for treatment of craving and relapse by which to disturb the addiction memory processes according to memory mechanism. Addiction memory is involved by many brain areas (such as the hippocampus, the prefrontal cortex, the ventral tagmental area, the rostromedial tegmental nucleus, and the habenula), which are interconnected by circuits and play crucial roles in normal learning and memory. This paper mainly reviews the recent research progress in treatment of addiction memory and the underlying neural circuits.

Key words: drug addiction, learning and memory, neurocircuitry