生物学杂志

生物学杂志

• 研究报告 • 上一篇    下一篇

大蒜素在鲫鱼体内的药动学及残留消除规律

  

  1. 1. 中国水产科学研究院 黑龙江水产研究所, 哈尔滨 150070; 2. 上海海洋大学 水产与生命学院, 上海 201306
  • 出版日期:2017-10-18 发布日期:2017-10-18
  • 通讯作者: 卢彤岩，研究员，主要从事水产动物病害研究，E-mail:lutongyan@hotmail.com
  • 作者简介:潘浩，硕士研究生，研究方向为鱼类病害研究,E-mail:zcph6666@126.com
  • 基金资助:
    公益性行业(农业)科研专项(201203085)；渔药使用风险评估及其控制技术研究与示范;现代农业产业技术体系建设专项资金项目（No.CARS-46）

Pharmacokinetics and residues of allicin in crucian carp

  1. 1. Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Harbin 150070;2. College of Fisheries and Life Science, Shanghai Ocean university, Shanghai 201306, China
  • Online:2017-10-18 Published:2017-10-18

PDF (PC)

126

摘要： 采用气相色谱法,研究了以7.5 mg/kg(体质量)单次剂量口灌给药后,大蒜素在鲫鱼体内的药物代谢动力学及药物残留消除规律。结果表明:单次口灌给药后,大蒜素在血浆中的药时关系符合一级吸收二室开放模型。每天一次，连续3 d给药后,大蒜素的主要成分: 二烯丙基二硫醚（DADS）于13 d开始低于10 μg/kg，二烯丙基三硫醚（DATS）于15 d开始低于10 μg/kg。研究表明,建议休药期不低于15 d。

关键词: 鲫鱼, 大蒜素, 药动学, 药物残留

Abstract: The pharmacokinetics and residues of allicin were studied in crucian carp exposed to oral administration at 7.5 mg/kg bodyweight by means of gas chromatography (GC)．The results showed that the concentrations versus time of allicin in muscle was well described by two-department open model with first-order absorption after a single oral administration．The residues in crucian carp by oral administration for 3 d once a day were found to be less than the maximum residue limit (MRL) (10 μg/kg) at the day 13 for DADS and the day 15 for DATS． The findings indicated that the withdrawal time should be 15 days after administration on these conditions．

Key words: crucian carp, allicin, pharmacokinetics, residue