生物学杂志

生物学杂志 ›› 2022, Vol. 39 ›› Issue (3): 94-.doi: 10.3969/j.issn.2095-1736.2022.03.094

• 综述与专论 • 上一篇    下一篇

先锋转录因子DUX4在人类胚胎合子基因组激活中的作用

  

  1. 同济大学附属第十人民医院， 上海 200072
  • 出版日期:2022-06-18 发布日期:2022-06-17
  • 通讯作者: 千日成，博士，教授，研究方向为卵子体外成熟和生育力保存，E-mail: rcchian@tongji.edu.cn
  • 作者简介:刘玉兵，博士，主管技师，研究方向为胚胎早期发育，E-mail: yubingliu@tongji.edu.cn
  • 基金资助:
    国家重点研发计划项目（2017YFC1002003）；国家自然科学基金项目（31601197）

Pioneer transcription factor DUX4 inzygotic genome activation during human embryo development #br# #br#

  1. Center for Reproductive Medicine, Tenth People’s Hospital of Tongji University, Shanghai 200072, China
  • Online:2022-06-18 Published:2022-06-17

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摘要： 总结近几年人类DUX4(double homeobox 4, DUX4)基因在细胞模型和早期胚胎基因组激活中的研究进展，发现先锋转录因子可与靶标基因的特定序列结合，诱导早期胚胎特异性染色质开放性建立及合子基因组激活（zygotic genome activation， ZGA），在母型-合子转换中发挥关键作用。探究先锋转录因子在人类早期胚胎ZGA中的作用，DUX4蛋白参与启动其他合子基因组激活基因的表达，可能是人类合子基因组激活的先锋转录因子，并对未来研究方向进行展望。

关键词: 　人类胚胎, 植入前胚胎发育, 合子基因组激活, 先锋转录因子, DUX4

Abstract: Mammalian life starts from zygote, which the oocyte is fertilized by the sperm. Subsequentmaternal-to-zygotic transition(MZT)is a crucial process in preimplantation embryo development.Pioneer transcription factors play a crucial role in the establishment of chromatin accessibility and zygotic genome activation initiation in early embryos through binding to specific sequences of target genes. However, the regulatory networks of pioneer transcription factor in human embryos remain unclear. Using the model of human embryonic stem cells, it has been found DUX4(double homeobox 4, DUX4) protein is the pivotal initiating factor for zygotic genome activation.The progress of human DUX4 in cell models and early embryo genome activation was summarized. Understanding the mechanism of zygotic genome activation in human preimplantation embryos may be helpful to optimize the in vitro culture system and to increase the success rate of assisted reproduction.

Key words: human embryos, preimplantation embryo development, zygotic genome activation, pioneer transcription factor, DUX4

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