生物学杂志

生物学杂志 ›› 2019, Vol. 36 ›› Issue (6): 82-.doi: 10.3969/j.issn.2095-1736.2019.06.082

• 综述与专论 • 上一篇    下一篇

LKB1-AMPKα信号转导通路在动物高脂血症中的调控作用 

  

  1. 安徽农业大学 动物科技学院， 合肥 230036
  • 出版日期:2019-12-18 发布日期:2019-12-12
  • 通讯作者: 李玉，副教授，硕士生导师，主要从事畜禽营养代谢病研究, E-mail:lydhy2014@ahau.edu.cn
  • 作者简介:明鹏飞，硕士研究生，主要从事畜禽营养代谢病研究, E-mail:1396648612@qq.com
  • 基金资助:

    安徽省自然科学基金项目（1608085QC56）；国家自然科学基金项目（31502136）；2016年省级大学生创新创业训练计划项目（201610364009）


Regulation of hyperlipidemia by LKB1-AMPKα signal transduction pathway in animals 

  1. College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China
  • Online:2019-12-18 Published:2019-12-12

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摘要：

动物高脂血症是指体内血浆脂质代谢紊乱，主要包括血浆总胆固醇、甘油三酯和低密度脂蛋白胆固醇含量升高以及高密度脂蛋白胆固醇水平降低。动物高脂血症会导致脂代谢紊乱的发生，进而导致2型糖尿病、胰岛素抵抗等代谢性疾病的发生，LKB1-AMPKα信号通路在动物高脂血症中起重要的调控作用，AMPK是一种丝氨酸/苏氨酸激酶，被称作“细胞能量监测器”，LKB1是AMPK的上游激酶，两者相互作用，共同调控高脂血症。因此阐明LKB1、AMPKα相互作用的上下游信号通路有可能成为新的治疗动物高脂血症等代谢性疾病的作用靶点。就LKB1-AMPKα信号通路在动物高脂血症中的调控作用做一综述，旨在为下一步研究高脂血症相关信号通路调控机制提供理论支持


关键词: LKB1, AMPKα, 动物, 高脂血症, 调控作用

Abstract:

Hyperlipidemia in animals refers to the disorder of plasma lipid metabolism in the body, mainly including the increase of plasma total cholesterol, triglyceride and low-density lipoprotein cholesterol, as well as the decrease of high-density lipoprotein cholesterol. The hyperlipidemia in animals can lead to the disorders of lipid metabolism, which in turn leads to the occurrence and development of metabolic diseases such as Type 2 diabetes and insulin resistance. LKB1-AMPKα signaling pathway plays an important role in the regulation of hyperlipidemia in animals. AMPK is a serine/threonine kinase, which is called “cell energy monitor”, LKB1 is the upstream kinase of AMPK, LKB1 and AMPKα interact and co-regulate the hyperlipidemia. Therefore, clarifying the upstream and downstream signaling pathways of LKB1 and AMPK interactions may become a new target for treatment of metabolic diseases such as hyperlipidemia. This article reviews the role of LKB1-AMPKα signaling pathways in the development and progression of hyperlipidemia, and the aims are to provide theoretical support for further research on the regulation mechanism of signaling transduction pathways associated with hyperlipidemia in animals.


Key words: LKB1, AMPKα, animals, hyperlipidemia, regulation

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